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Comparative Study
. 1986 Feb;13(2):169-71.
doi: 10.1111/j.1440-1681.1986.tb00332.x.

Neuromuscular blocking activity of a crude aqueous extract of Ipomoea fistulosa

A A Abdelhadi, Y M Elkheir, T Hassan, A A Mustafa
Comparative Study

Neuromuscular blocking activity of a crude aqueous extract of Ipomoea fistulosa

A A Abdelhadi et al. Clin Exp Pharmacol Physiol. 1986 Feb.

Abstract

The rat phrenic nerve hemidiaphragm and chick biventer-cervicis preparations were used to investigate the effect of a crude aqueous extract of Ipomoea fistulosa. Electrically-induced skeletal muscle twitches of the hemidiaphragm were blocked by the extract and by tubocurarine. The anticholinesterase, physostigmine, intensified the blockade by the extract. The extract produced contracture of the chick biventer-cervicis preparation. It is suggested that the extract possesses neuromuscular blocking activity of a depolarizing nature.

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