Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep;159 Suppl 1(Suppl 1):S65-S73.
doi: 10.1097/j.pain.0000000000001329.

A bright future? Optogenetics in the periphery for pain research and therapy

Aaron D Mickle  1 , Robert W Gereau 4th
Affiliations
Review

A bright future? Optogenetics in the periphery for pain research and therapy

Aaron D Mickle et al. Pain. 2018 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Peripheral Light Delivery Technology for Optogenetics. A and B) Wirelessly powered µLED device for stimulation of spinal afferents or spinal cord neurons. Reproduced from reference [95] with permission. C and D) µLED device for illuminating opsins in the bladder or lower abdomen. Additional encapsulation layers provide protection from mechanical forces and repetitive stresses associated with subcutaneous abdominal implants. Reproduced from reference [94] with permission. E) Multi-purpose wireless µLED device that can target opsins expressed in various brain regions and peripheral tissues. Reproduced from reference [100] with permission. F) Illustration of a multi-use wireless µLED device used to target colon afferents. Reproduced from reference [50] with permission. G and D) Demonstration of a nanowire system, for electrical recording and optical stimulation of spinal cord neurons [67].
See this image and copyright information in PMC

References

    1. Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature. 2009;458(7241):1025–1029. - PubMed
    1. Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA, Lechner SG. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron. 2017;93(1):179–193. - PubMed
    1. Baumbauer KM, DeBerry JJ, Adelman PC, Miller RH, Hachisuka J, Lee KH, Ross SE, Koerber HR, Davis BM, Albers KM. Keratinocytes can modulate and directly initiate nociceptive responses. eLife. 2015;4 - PMC - PubMed
    1. Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Seguela P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers. Pain. 2017;158(12):2329–2339. - PubMed
    1. Berndt A, Schoenenberger P, Mattis J, Tye KM, Deisseroth K, Hegemann P, Oertner TG. High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(18):7595–7600. - PMC - PubMed