Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Mar;5(3):553-60.
doi: 10.1002/j.1460-2075.1986.tb04246.x.

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells

C Wasylyk, B Wasylyk

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells

C Wasylyk et al. EMBO J. 1986 Mar.

Abstract

The mouse immunoglobulin heavy-chain (IgH) B-lymphocyte enhancer stimulates transcription from heterologous promoters 20- to 40-fold when transfected into several non-lymphoid cell lines. Stimulation in B-lymphocyte melanoma cell-lines is only about 5--10 times better. A central sequence is equally active in both cell types, whilst flanking sequences, on either side of the common enhancer sequences, specifically stimulate transcription in myeloma cells. These results suggest that there are factors in non-lymphoid cells that can interact with the IgH enhancer to stimulate transcription.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell Differ. 1976 Mar;4(6):369-83 - PubMed
    1. Nature. 1985 Dec 5-11;318(6045):475-8 - PubMed
    1. Nature. 1981 Nov 5;294(5836):90-2 - PubMed
    1. Somatic Cell Genet. 1981 Sep;7(5):603-16 - PubMed
    1. Nucleic Acids Res. 1981 Nov 25;9(22):6047-68 - PubMed

Publication types