doi: 10.1007/BF01946700.
Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation
- PMID: 3011492
- DOI: 10.1007/BF01946700
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Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation
Experientia.
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Abstract
NADPH dependent H2O2 formation in microsomes in the presence of chelated iron leads to formation of hydroxyl radicals. Enhancement of hydroxyl radical generation (via ferric-EDTA or sodium azide) did not result in a concomitant increase in lipid peroxidation; rather, a decrease was observed. Moreover, the hydroxyl radical scavenger DMSO did not inhibit lipid peroxidation. This comparison of hydroxyl radical formation with lipid peroxidation suggests that hydroxyl radicals do not play a part in NADPH-dependent lipid peroxidation.
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