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. 1986 May 15;42(5):555-6.
doi: 10.1007/BF01946700.

Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation

A Bast, M H Steeghs

Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation

A Bast et al. Experientia. .

Abstract

NADPH dependent H2O2 formation in microsomes in the presence of chelated iron leads to formation of hydroxyl radicals. Enhancement of hydroxyl radical generation (via ferric-EDTA or sodium azide) did not result in a concomitant increase in lipid peroxidation; rather, a decrease was observed. Moreover, the hydroxyl radical scavenger DMSO did not inhibit lipid peroxidation. This comparison of hydroxyl radical formation with lipid peroxidation suggests that hydroxyl radicals do not play a part in NADPH-dependent lipid peroxidation.

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