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Multicenter Study
. 2018 Aug 16;19(1):206.
doi: 10.1186/s12882-018-0996-0.

Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients

Chaomin Zhou  1 , Hongying Peng  2 , Jing Yuan  1 , Xin Lin  1 , Yan Zha  3 , Hui Chen  4
Affiliations
Multicenter Study

Visceral, general, abdominal adiposity and atherogenic index of plasma in relatively lean hemodialysis patients

Chaomin Zhou et al. BMC Nephrol. .

Abstract

Background: Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed to explore and compare the associations between different adiposity indices reflecting general, abdominal, visceral adiposity and arteriosclerosis risk with atherogenic index of plasma(AIP) in relatively lean MHD patients.

Methods: We conducted a multicenter, cross-sectional study in Guizhou Province, Southwest China. General/abdominal adiposity indices like body mass index (BMI), waist circumference(WC), waist-height ratio(WHtR), conicity index (Ci) and visceral obesity indices including visceral adiposity index (VAI), lipid accumulation product (LAP) and the hypertriglyceridemic waist phenotype (HW phenotype) were recorded. Univariate and multivariate linear regression models were used.

Results: All adiposity indices correlated positively with AIP in univariate analysis both in men and women except for Ci. After adjustment for age and traditional atherosclerosis risk factors, BMI, WC, WHtR, VAI and LAP still had associations with AIP both in men (β = 0.265, 0.153, 0.16, 0.788 and 0.74, respectively, all P < 0.001) and women (β = 0.34,0.199, 0.21, 0.83 and 0.74, respectively, all P < 0.001). After further adjustment for BMI, associations between AIP and VAI, LAP remained significant, but associations between WC, WHtR and AIP disappeared.

Conclusions: The HW phenotype, VAI, and LAP, validated and convenient markers of visceral obesity, were superior to classical anthropometric general/ abdominal adiposity indices for atherosclerosis risk assessment, especially in relatively lean MHD patients aged 40 years or older.

Keywords: Atherogenic index of plasma; Hemodialysis; Visceral adiposity.

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Conflict of interest statement

Ethics approval and consent to participate

Ethics Committee of The People’s Hospital of Guizhou province approved the study, with written consent obtained. All participants were voluntary to take part in our study and had submitted their written consent.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Relationship between body mass index (BMI), waist circumference(WC), waist-height ratio(WHtR) and atherogenic index of plasma (AIP). a entire subjects; b Men; c women
See this image and copyright information in PMC

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