doi: 10.1016/0014-5793(86)80561-0.
Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
- PMID: 3011507
- DOI: 10.1016/0014-5793(86)80561-0
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Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
FEBS Lett.
.
Free article
Abstract
In the guinea pig myometrium prelabelled with myo-[2-3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP3 which preceded that of IP2 and IP1. The specific receptor-mediated phospholipase C activation degrading PIP2 to IP3 did not require the presence of extracellular Ca2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.
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