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Comment
. 2018 Sep 3;150(9):1231-1232.
doi: 10.1085/jgp.201812197. Epub 2018 Aug 16.

Propofol's paradox, explained

Caitlin Sedwick
Comment

Propofol's paradox, explained

Caitlin Sedwick. J Gen Physiol. .

Abstract

Tandem JGP studies investigate how propofol affects voltage-gated sodium channels.

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Figures

None
Elaine Yang and Manuel Covarrubias, in parallel with Yali Wang and Yan Xu, authored tandem JGP papers investigating how propofol achieves inhibition of voltage-gated sodium channels. Both labs collaborated with colleagues in a multi-institutional investigatory group (not shown) studying the mechanisms of anesthesia. At right: Molecular dynamics simulation of propofol interacting with the channel. Photos courtesy of the authors.
See this image and copyright information in PMC

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References

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