Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

doi:10.3389/fmicb.2018.01797

Review

. 2018 Aug 2:9:1797.

doi: 10.3389/fmicb.2018.01797. eCollection 2018.

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Peter Nambala¹, Wen-Chi Su^{1

2}

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
² Research Center for Emerging Viruses, China Medical University Hospital, Taichung, Taiwan.

PMID: 30116235
PMCID: PMC6083217
DOI: 10.3389/fmicb.2018.01797

Review

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Peter Nambala et al. Front Microbiol. 2018.

. 2018 Aug 2:9:1797.

doi: 10.3389/fmicb.2018.01797. eCollection 2018.

Authors

Peter Nambala¹, Wen-Chi Su^{1

2}

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
² Research Center for Emerging Viruses, China Medical University Hospital, Taichung, Taiwan.

PMID: 30116235
PMCID: PMC6083217
DOI: 10.3389/fmicb.2018.01797

Abstract

Recent Zika virus (ZIKV) epidemics necessitate the urgent development of effective drugs and vaccines, which can be accelerated by an enhanced understanding of ZIKV biology. One of the ZIKV structural proteins, precursor membrane (prM), plays an important role in the assembly of mature virions through cleavage of prM into M protein. Recent studies have suggested that prM protein might be implicated in the neurovirulence of ZIKV. Most vaccines targeting ZIKV include prM as the immunogen. Here, we review progress in our understanding of ZIKV prM protein and its application in ZIKV vaccine development.

Keywords: ZIKV; epidemic; prM; vaccine; viral pathogenicity.

PubMed Disclaimer

Cited by

Site-specific N-glycosylation analysis of animal cell culture-derived Zika virus proteins.
Pralow A, Nikolay A, Leon A, Genzel Y, Rapp E, Reichl U. Pralow A, et al. Sci Rep. 2021 Mar 4;11(1):5147. doi: 10.1038/s41598-021-84682-z. Sci Rep. 2021. PMID: 33664361 Free PMC article.
Assay Challenges for Emerging Infectious Diseases: The Zika Experience.
Roberts CC, Maslow JN. Roberts CC, et al. Vaccines (Basel). 2018 Oct 2;6(4):70. doi: 10.3390/vaccines6040070. Vaccines (Basel). 2018. PMID: 30279372 Free PMC article. Review.
Development and optimization of a Zika virus antibody-dependent cell-mediated cytotoxicity (ADCC) assay.
Chen X, Anderson LJ, Rostad CA, Ding L, Lai L, Mulligan M, Rouphael N, Natrajan MS, McCracken C, Anderson EJ. Chen X, et al. J Immunol Methods. 2021 Jan;488:112900. doi: 10.1016/j.jim.2020.112900. Epub 2020 Oct 16. J Immunol Methods. 2021. PMID: 33075363 Free PMC article.
The Evolving Role of Zika Virus Envelope Protein in Viral Entry and Pathogenesis.
Roozitalab A, Zhang J, Zhang C, Tang Q, Zhao RY. Roozitalab A, et al. Viruses. 2025 Jun 6;17(6):817. doi: 10.3390/v17060817. Viruses. 2025. PMID: 40573410 Free PMC article. Review.
An Evolutionary Insight into Zika Virus Strains Isolated in the Latin American Region.
Simón D, Fajardo A, Moreno P, Moratorio G, Cristina J. Simón D, et al. Viruses. 2018 Dec 8;10(12):698. doi: 10.3390/v10120698. Viruses. 2018. PMID: 30544785 Free PMC article.

See all "Cited by" articles

References

1. Adekolu-John E. O., Fagbami A. H. (1983). Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980. Trans. R. Soc. Trop. Med. Hyg 77 149–151. 10.1016/0035-9203(83)90053-6 - DOI - PubMed
1. Atkinson B., Hearn P., Afrough B., Lumley S., Carter D., Aarons E. J., et al. (2016). Detection of Zika virus in Semen. Emerg. Infect. Dis 22:940. 10.3201/eid2205.160107 - DOI - PMC - PubMed
1. Bos S., Viranaicken W., Turpin J., El-Kalamouni C., Roche M., Krejbich-Trotot P., et al. (2018). The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Virology 516 265–273. 10.1016/j.virol.2017.12.003 - DOI - PubMed
1. Buathong R., Hermann L., Thaisomboonsuk B., Rutvisuttinunt W., Klungthong C., Chinnawirotpisan P., et al. (2015). Detection of zika virus infection in thailand, 2012-2014. Am. J. Trop. Med. Hyg. 93 380–383. 10.4269/ajtmh.15-0022 - DOI - PMC - PubMed
1. Chahal J. S., Fang T., Woodham A. W., Khan O. F., Ling J., Anderson D. G., et al. (2017). An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci. Rep. 7:252. 10.1038/s41598-017-00193-w - DOI - PMC - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

[1] Adekolu-John E. O., Fagbami A. H. (1983). Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980. Trans. R. Soc. Trop. Med. Hyg 77 149–151. 10.1016/0035-9203(83)90053-6 - DOI - PubMed

[2] Adekolu-John E. O., Fagbami A. H. (1983). Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980. Trans. R. Soc. Trop. Med. Hyg 77 149–151. 10.1016/0035-9203(83)90053-6 - DOI - PubMed

[3] Atkinson B., Hearn P., Afrough B., Lumley S., Carter D., Aarons E. J., et al. (2016). Detection of Zika virus in Semen. Emerg. Infect. Dis 22:940. 10.3201/eid2205.160107 - DOI - PMC - PubMed

[4] Atkinson B., Hearn P., Afrough B., Lumley S., Carter D., Aarons E. J., et al. (2016). Detection of Zika virus in Semen. Emerg. Infect. Dis 22:940. 10.3201/eid2205.160107 - DOI - PMC - PubMed

[5] Bos S., Viranaicken W., Turpin J., El-Kalamouni C., Roche M., Krejbich-Trotot P., et al. (2018). The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Virology 516 265–273. 10.1016/j.virol.2017.12.003 - DOI - PubMed

[6] Bos S., Viranaicken W., Turpin J., El-Kalamouni C., Roche M., Krejbich-Trotot P., et al. (2018). The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Virology 516 265–273. 10.1016/j.virol.2017.12.003 - DOI - PubMed

[7] Buathong R., Hermann L., Thaisomboonsuk B., Rutvisuttinunt W., Klungthong C., Chinnawirotpisan P., et al. (2015). Detection of zika virus infection in thailand, 2012-2014. Am. J. Trop. Med. Hyg. 93 380–383. 10.4269/ajtmh.15-0022 - DOI - PMC - PubMed

[8] Buathong R., Hermann L., Thaisomboonsuk B., Rutvisuttinunt W., Klungthong C., Chinnawirotpisan P., et al. (2015). Detection of zika virus infection in thailand, 2012-2014. Am. J. Trop. Med. Hyg. 93 380–383. 10.4269/ajtmh.15-0022 - DOI - PMC - PubMed

[9] Chahal J. S., Fang T., Woodham A. W., Khan O. F., Ling J., Anderson D. G., et al. (2017). An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci. Rep. 7:252. 10.1038/s41598-017-00193-w - DOI - PMC - PubMed

[10] Chahal J. S., Fang T., Woodham A. W., Khan O. F., Ling J., Anderson D. G., et al. (2017). An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci. Rep. 7:252. 10.1038/s41598-017-00193-w - DOI - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Affiliations

Role of Zika Virus prM Protein in Viral Pathogenicity and Use in Vaccine Development

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Similar articles

Cited by

References

Publication types

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources