Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease

doi:10.1002/ajh.25258

. 2018 Nov;93(11):E376-E380.

doi: 10.1002/ajh.25258. Epub 2018 Oct 17.

Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease

Rasha Raslan¹, Binal N Shah¹, Xu Zhang¹, Tamir Kanias², Jin Han³, Roberto F Machado⁴, Mark T Gladwin², Victor R Gordeuk¹, Santosh L Saraf¹

Affiliations

¹ Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois.
² Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
³ Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois.
⁴ Division of Pulmonary and Critical Care, Department of Medicine, Indiana University, Indianapolis, Indiana.

PMID: 30117177
PMCID: PMC6196103
DOI: 10.1002/ajh.25258

Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease

Rasha Raslan et al. Am J Hematol. 2018 Nov.

. 2018 Nov;93(11):E376-E380.

doi: 10.1002/ajh.25258. Epub 2018 Oct 17.

Authors

Rasha Raslan¹, Binal N Shah¹, Xu Zhang¹, Tamir Kanias², Jin Han³, Roberto F Machado⁴, Mark T Gladwin², Victor R Gordeuk¹, Santosh L Saraf¹

Affiliations

¹ Division of Hematology and Oncology, Department of Medicine, Comprehensive Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois.
² Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
³ Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois.
⁴ Division of Pulmonary and Critical Care, Department of Medicine, Indiana University, Indianapolis, Indiana.

PMID: 30117177
PMCID: PMC6196103
DOI: 10.1002/ajh.25258

No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

**Figure 1A:**
Age of SCD patients categorized by decile in the UIC (A) and Walk-PHaSST (B) cohorts.

**Figure 1B:**
Hemolytic markers categorized by age decile in the UIC cohort (mean and standard error bars provided).

**Figure 1C:**
Hemolytic markers by age decile in the Walk-PHaSST cohort (mean and standard error bars provided).

See this image and copyright information in PMC

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References

1. Arias E, Heron M, Xu J. United States Life Tables, 2013. Natl Vital Stat Rep 2017;66:1–64. - PubMed
1. Gladwin MT, Barst RJ, Gibbs JS, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One 2014;9:e99489. - PMC - PubMed
1. Kanias T, Sinchar D, Osei-Hwedieh D, et al. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion 2016;56:2571–2583. - PMC - PubMed
1. Dover GJ, Smith KD, Chang YC, et al. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood 1992;80:816–824. - PubMed
1. Motulsky AG, Yoshida A, Stamatoyannopoulos G. Variants of glucose-6-phosphate dehydrogenase. Ann N Y Acad Sci 1971;179:636–643. - PubMed

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[1] Arias E, Heron M, Xu J. United States Life Tables, 2013. Natl Vital Stat Rep 2017;66:1–64. - PubMed

[2] Arias E, Heron M, Xu J. United States Life Tables, 2013. Natl Vital Stat Rep 2017;66:1–64. - PubMed

[3] Gladwin MT, Barst RJ, Gibbs JS, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One 2014;9:e99489. - PMC - PubMed

[4] Gladwin MT, Barst RJ, Gibbs JS, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One 2014;9:e99489. - PMC - PubMed

[5] Kanias T, Sinchar D, Osei-Hwedieh D, et al. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion 2016;56:2571–2583. - PMC - PubMed

[6] Kanias T, Sinchar D, Osei-Hwedieh D, et al. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease. Transfusion 2016;56:2571–2583. - PMC - PubMed

[7] Dover GJ, Smith KD, Chang YC, et al. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood 1992;80:816–824. - PubMed

[8] Dover GJ, Smith KD, Chang YC, et al. Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2. Blood 1992;80:816–824. - PubMed

[9] Motulsky AG, Yoshida A, Stamatoyannopoulos G. Variants of glucose-6-phosphate dehydrogenase. Ann N Y Acad Sci 1971;179:636–643. - PubMed

[10] Motulsky AG, Yoshida A, Stamatoyannopoulos G. Variants of glucose-6-phosphate dehydrogenase. Ann N Y Acad Sci 1971;179:636–643. - PubMed

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Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease

Affiliations

Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease

Authors

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Conflict of interest statement

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