Dysregulating ClpP: From Antibiotics to Anticancer?
- PMID: 30118671
- DOI: 10.1016/j.chembiol.2018.08.002
Dysregulating ClpP: From Antibiotics to Anticancer?
Abstract
In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.Cell Chem Biol. 2018 Aug 16;25(8):1017-1030.e9. doi: 10.1016/j.chembiol.2018.05.014. Epub 2018 Jun 28. Cell Chem Biol. 2018. PMID: 30126533
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