Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging
- PMID: 30118677
- DOI: 10.1016/j.molcel.2018.08.002
Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging
Abstract
By systemically boosting autophagy with a knockin mutation that prevents binding of beclin 1 to BCL2, Fernández et al. (2018) demonstrate that enhanced autophagy prolongs lifespan in mammals.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.Nature. 2018 Jun;558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Nature. 2018. PMID: 29849149 Free PMC article.
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