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Meta-Analysis
. 2018 Aug 17;17(1):192.
doi: 10.1186/s12944-018-0827-0.

The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis

Yangquan Hao  1 , Hao Guo  2 , Zhaochen Xu  2 , Handeng Qi  3 , Yugui Wang  3 , Chao Lu  2 , Jie Liu  3 , Puwei Yuan  4
Affiliations
Meta-Analysis

The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis

Yangquan Hao et al. Lipids Health Dis. .

Abstract

Background: The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH).

Methods: The relevant literature was screened from databases of Pubmed, Embase, Wanfang, Weipu and China National Knowledge Internet (CNKI) until May, 2017. In addition, odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as a measure of effect size for calculating effect size.

Results: Totally, six case-control studies were included in this meta-analysis. It revealed that ApoB-C7623T polymorphism frequency was increased in ONFH group than in control group under three genetic models, including allele model (T vs. C, OR = 4.5149, 95% CI: 1.6968-12.0134); additive model (TC vs. CC, OR = 6.2515, 95% CI: 2.0939-18.6640); and dominant model (TT + TC vs. CC, OR = 5.4998, 95% CI: 1.9246-15.7163). In addition, the increased risk of ONFH were related to ApoA1-rs1799837 polymorphism under additive model (AA vs. GG, OR = 1.4175, 95% CI: 1.0522-1.9096) and recessive model (AA vs. GG + AG, OR = 1.7727, 95% CI: 1.3399-2.3452). However, four ApoB rs1042031, rs693, 3'-VNTR and G12619A polymorphisms under the all genetic models were not associated with susceptibility to ONFH.

Conclusion: The T allele and TC genotype of ApoB-C7623T and AA genotype of ApoA1-rs1799837 may contribute to increase the risk of ONFH.

Keywords: Apolipoprotein A1; Apolipoprotein B; Genetic model; Meta-analysis; Osteonecrosis of the femoral head; Polymorphism.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow chart shows the selection process of eligible studies
Fig. 2
Fig. 2
Forest plot of the quantitative synthesis of ApoB-3′-VNTR in ONFH and non-ONFH groups. ONFH: Osteonecrosis of the femoral head. ApoB: apolipoprotein B
Fig. 3
Fig. 3
Forest plot of the quantitative synthesis of ApoB-G12619A in ONFH and non-ONFH groups. ONFH: Osteonecrosis of the femoral head. ApoB: apolipoprotein B
Fig. 4
Fig. 4
Forest plot of the quantitative synthesis of ApoB-C7623T in ONFH and non-ONFH groups. ONFH: Osteonecrosis of the femoral head. ApoA1: apolipoprotein A1
Fig. 5
Fig. 5
Forest plot of the quantitative synthesis of ApoB-rs1042031 in ONFH and non-ONFH groups. ONFH: Osteonecrosis of the femoral head. ApoB: apolipoprotein B
Fig. 6
Fig. 6
Forest plot of the quantitative synthesis of ApoB-rs693 in ONFH and non-ONFH groups. Squares denote the study-specific outcome estimates, and the size of the square represents the study-specific weight. ONFH: Osteonecrosis of the femoral head. ApoB: apolipoprotein B
Fig. 7
Fig. 7
Forest plot of the quantitative synthesis of Apo A1-rs1799837 in ONFH and non-ONFH groups. ONFH: Osteonecrosis of the femoral head. ApoB: apolipoprotein B
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