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Comment
. 2018 Oct;26(10):813-814.
doi: 10.1016/j.tim.2018.08.001. Epub 2018 Aug 14.

Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche

Michael D Stutz  1 , Marc Pellegrini  2
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Comment

Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche

Michael D Stutz et al. Trends Microbiol. 2018 Oct.

Abstract

Mycobacterium tuberculosis interferes with the ability of its host cell to undergo apoptosis. Arnett et al. report that the pathogen promotes macrophage survival by engaging the nuclear receptor PPARγ to induce the antiapoptotic protein MCL-1, yielding insights into the pathogenesis of tuberculosis and potentially unlocking new avenues for therapeutic intervention.

Keywords: MCL-1; PPARγ; apoptosis; host-directed therapy; tuberculosis.

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