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Review
. 2018 Aug 18;18(10):85.
doi: 10.1007/s11892-018-1053-x.

Genetics of Severe Obesity

Una Fairbrother  1 , Elliot Kidd  1 , Tanya Malagamuwa  2 , Andrew Walley  3
Affiliations
Review

Genetics of Severe Obesity

Una Fairbrother et al. Curr Diab Rep. .

Abstract

Purpose of review: This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R.

Recent findings: There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity. The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population.

Keywords: BMI; GWAS; Leptin; Melanocortin-4 receptor; Obesity.

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Conflict of interest statement

Conflict of Interest

Una Fairbrother, Elliot Kidd, Tanya Malagamuwa and Andrew Walley declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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