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. 2018 Jul;70 Suppl 1(Suppl 1):S111-S117.
doi: 10.1016/j.ihj.2018.01.031. Epub 2018 Jan 31.

Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

Mehdi Jafari  1 , Seyed Masood Mousavi  2 , Asra Asgharzadeh  3 , Neda Yazdani  4
Affiliations

Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

Mehdi Jafari et al. Indian Heart J. 2018 Jul.

Abstract

Introduction: This article is an attempt to provide an overview of systematic reviews to determine the efficacy of CQ10 supplementation in the treatment of patients with cardiovascular diseases (CVD).

Method and material: All reviews were identified through a systematic search of the following databases: Cochrane, DARE, Ovid, EMBASE, ISI Web of Knowledge, and PubMed. Check references studies and the quality of the studies was assessed by means of AMSTTAR. No meta-analyses were performed due to the heterogeneity of studies.

Result: Extracted data for Seven systematic reviews for primary outcomes, net changes in cardiac output, cardiac index, New York Heart Association functional classification, improved survival, based on existing evidence, there is a case for use of CoQ10 as an adjunctive therapy in congestive heart failure, especially in those patients unable to tolerate mainstream medical therapies.

Conclusion: Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.

Keywords: Cardiovascular; Coenzyme Q10; Systematic review.

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