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Review
. 2018 Aug 1:11:1445-1457.
doi: 10.2147/JPR.S168705. eCollection 2018.

Non-invasive brain stimulation in chronic orofacial pain: a systematic review

Alberto Herrero Babiloni  1 , Samuel Guay  1 , Donald R Nixdorf  2   3 , Louis de Beaumont  1 , Gilles Lavigne  1
Affiliations
Review

Non-invasive brain stimulation in chronic orofacial pain: a systematic review

Alberto Herrero Babiloni et al. J Pain Res. .

Abstract

Background: Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation techniques that are being explored as therapeutic alternatives for the management of various chronic pain conditions.

Objective: The primary objective of this systematic review is to assess the efficacy of TMS and tDCS in reducing clinical pain intensity in chronic orofacial pain (OFP) disorders. The secondary objectives are to describe adverse effects, duration of relief, and TMS/tDCS methodologies used in chronic OFP disorders.

Methods: A search was performed in MEDLINE, Embase, Web of Science, Scopus, and Google Scholar. Inclusion criteria were 1) population: adults diagnosed with chronic OFP including neuropathic and non-neuropathic disorders; 2) intervention: active TMS or tDCS stimulation regardless of the used protocol; 3) comparison: sham TMS or tDCS stimulation; and 4) outcome: primary outcome was patient reported pain intensity. Secondary outcomes were duration of pain relief, adverse effects, and methodological parameters. Risk of bias and quality of study reporting were also assessed.

Results: A total of 556 individual citations were identified by the search strategy, with 14 articles meeting selection criteria (TMS=11; tDCS=3). Data were obtained for a total of 228 patients. Included OFP disorders were trigeminal neuralgia, trigeminal neuropathy, burning mouth syndrome, atypical facial pain, and temporomandibular disorders. Significant pain reductions were obtained in both techniques. More number of sessions yielded to more durable effects. Overall, high risk of bias and poor study quality were found.

Conclusion: TMS and tDCS appear to be safe and promising alternatives to reduce pain intensity in different chronic OFP disorders. Additional research effort is needed to reduce bias, improve quality, and characterize optimal brain stimulation parameters to promote their efficacy.

Keywords: cortex; facial pain; transcranial direct current stimulation; transcranial magnetic stimulation; treatment.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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References

    1. Benoliel R, Sharav Y. Chronic orofacial pain. Curr Pain Headache Rep. 2010;14(1):33–40. - PubMed
    1. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc. 1993;124(10):115–121. - PubMed
    1. Reisine ST, Weber J. The effects of temporomandibular joint disorders on patients’ quality of life. Community Dent Health. 1989;6(3):257–270. - PubMed
    1. Shueb SS, Nixdorf DR, John MT, Alonso BF, Durham J. What is the impact of acute and chronic orofacial pain on quality of life? J Dent. 2015;43(10):1203–1210. - PubMed
    1. Chronic Pain Research Alliance Impact of Chronic Overlapping Pain Conditions on Public Health and the Urgent Need for Safe and Effective Treatment. 2015. [Accessed August 17, 2016]. pp. 1–46. Available from: http://www.chronicpainresearch.org/public/CPRA_WhitePaper_2015-FINAL-Dig....

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