Urinary Orosomucoid A Potential Marker Of Inflammation In Psoriasis

Abstract

Background: Psoriasis is one of the most common chronic, life-long dermatologic diseases, which has considerable negative effects on quality of life. Psoriasis is considered as a systemic inflammatory disease, thus acute phase proteins such as C-reactive protein (CRP) and orosomucoid (ORM) have been shown to play a role in its pathophysiology. This study was aimed to compare CRP, serum ORM (se-ORM) and urinary ORM (u-ORM) levels of psoriatic patients to healthy individuals. Methods: 87 psoriatic patients and 41 healthy individuals were enrolled. Simultaneously obtained venous blood and spot urine samples were analysed. High sensitivity CRP and se-ORM levels were determined by routine procedures on automated analyzers. Urinary ORM was measured by a novel automated turbidimetric assay. U-ORM was referred to urinary creatinine (u-ORM/u-CREAT, mg/mmol). Results: Significantly higher hsCRP (p<0.001) and u-ORM/u-CREAT (p=0.001) levels were found among psoriatic patients compared to controls. No significant differences were found between the groups regarding se-ORM levels. HsCRP, se-ORM and u-ORM/u-CREAT levels were significantly higher in patients with severe psoriasis than in mild and moderate cases (p<0.05). Conclusion: As a highly sensitive, easily available biomarker u-ORM shows itself capable of becoming a new inflammatory marker in psoriasis providing clinically useful information on disease severity.

Keywords: Orosomucoid; Psoriasis; Urine, Biomarker, Inflammation.

Figure 1

U-ORM/u-CREAT levels in psoriatic patients. A: u-ORM/u-CREAT levels in psoriasis compared to healthy controls. B: u-ORM/u-CREAT levels based on Psoriasis Area and Severity Index (PASI), mild: PASI<7, moderate: PASI:7-12, severe: PASI>12. C: u-ORM/u-CREAT levels in psoriatic arthritis, n.s.: not significant (p=0.23)