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Review
. 2018 Jul 30;9(16):2852-2864.
doi: 10.7150/jca.25460. eCollection 2018.

The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma

Chunmei Fan  1   2   3 , Yanyan Tang  1   2 , Jinpeng Wang  2 , Fang Xiong  3 , Can Guo  2 , Yumin Wang  2 , Bo Xiang  2 , Ming Zhou  2 , Xiayu Li  2   4 , Xu Wu  2   5 , Yong Li  2   6 , Xiaoling Li  1   2   3 , Guiyuan Li  1   2   3 , Wei Xiong  1   2   3 , Zhaoyang Zeng  1   2   3
Affiliations
Review

The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma

Chunmei Fan et al. J Cancer. .

Abstract

Epstein-Barr virus (EBV) is an oncogenic herpes virus that is closely associated with the initiation and development of nasopharyngeal carcinoma (NPC), lymphoma and other malignant tumors. EBV encodes 44 mature miRNAs that regulate viral and host cell gene expression and plays a variety of roles in biological functions and the development of cancer. In this review, we summarized the biological functions and molecular mechanisms of Epstein-Barr virus-encoded microRNAs (EBV miRNAs) in tumor immune evasion, proliferation, anti-apoptosis, invasion, metastasis and as a potential biomarker for NPC diagnosis and prognosis. The knowledge generated by EBV miRNAs can be used for EBV miRNA-based precision cancer treatments in the near future.

Keywords: EBV miRNAs; anti-apoptosis; biomarker; immune evasion; metastasis; nasopharyngeal carcinoma.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
Role of EBV miRNAs in immune evasion and EBV latency. EBV miRNAs can be secreted from infected B cells to non-infected cells via exosomes. EBV miRNAs regulate lymphocyte activation and lethality, modulate infected host cell antigens and maintain EBV latent infection status to establish persistent latent infections.
Fig 2
Fig 2
Role of EBV miRNAs in signaling pathways. EBV miRNAs can modulate viral and host cell gene expression by directly or indirectly regulating molecules and related signaling pathways.
See this image and copyright information in PMC

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