Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Jul;10(Suppl 18):S2130-S2132.
doi: 10.21037/jtd.2018.06.45.

Is alectinib the new first line therapy in ALK-rearranged advanced non-small cell lung cancer?

Affiliations
Editorial

Is alectinib the new first line therapy in ALK-rearranged advanced non-small cell lung cancer?

Anthonie J van der Wekken et al. J Thorac Dis. 2018 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

References

    1. Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703. Erratum in: N Engl J Med 2011;364:588. 10.1056/NEJMoa1006448 - DOI - PMC - PubMed
    1. van der Wekken AJ, Pelgrim R, 't Hart N, et al. Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non-Small Cell Lung Cancer. Clin Cancer Res 2017;23:4251-8. 10.1158/1078-0432.CCR-16-1631 - DOI - PubMed
    1. Gadgeel SM, Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 2014;15:1119-28. 10.1016/S1470-2045(14)70362-6 - DOI - PubMed
    1. Friboulet L, Li N, Katayama R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 2014;4:662-73. 10.1158/2159-8290.CD-13-0846 - DOI - PMC - PubMed
    1. Cui JJ, Zhai D, Deng W, et al. TPX-0005, a novel ALK/ROS1/TRK inhibitor, effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants. Eur J Cancer 2016;69:S32 10.1016/S0959-8049(16)32675-2 - DOI

LinkOut - more resources