Is alectinib the new first line therapy in ALK-rearranged advanced non-small cell lung cancer?
- PMID: 30123541
- PMCID: PMC6072953
- DOI: 10.21037/jtd.2018.06.45
Is alectinib the new first line therapy in ALK-rearranged advanced non-small cell lung cancer?
Conflict of interest statement
Conflicts of Interest: The authors have no conflicts of interest to declare.
Comment on
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Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J-ALEX): an open-label, randomised phase 3 trial.Lancet. 2017 Jul 1;390(10089):29-39. doi: 10.1016/S0140-6736(17)30565-2. Epub 2017 May 10. Lancet. 2017. PMID: 28501140 Clinical Trial.
References
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- Gadgeel SM, Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 2014;15:1119-28. 10.1016/S1470-2045(14)70362-6 - DOI - PubMed
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- Friboulet L, Li N, Katayama R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 2014;4:662-73. 10.1158/2159-8290.CD-13-0846 - DOI - PMC - PubMed
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- Cui JJ, Zhai D, Deng W, et al. TPX-0005, a novel ALK/ROS1/TRK inhibitor, effectively inhibited a broad spectrum of mutations including solvent front ALK G1202R, ROS1 G2032R and TRKA G595R mutants. Eur J Cancer 2016;69:S32 10.1016/S0959-8049(16)32675-2 - DOI
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