Timing of high intensity statin for acute coronary syndrome: how earlier initiation makes better?

Choongki Kim¹, Donghoon Choi^{1

2}

Affiliations

¹ Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
² Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Editorial

Choongki Kim et al. J Thorac Dis. 2018 Jul.

. 2018 Jul;10(Suppl 18):S2149-S2152.

doi: 10.21037/jtd.2018.06.46.

Choongki Kim¹, Donghoon Choi^{1

2}

¹ Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
² Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial.
Berwanger O, Santucci EV, de Barros E Silva PGM, Jesuíno IA, Damiani LP, Barbosa LM, Santos RHN, Laranjeira LN, Egydio FM, Borges de Oliveira JA, Dall Orto FTC, Beraldo de Andrade P, Bienert IRC, Bosso CE, Mangione JA, Polanczyk CA, Sousa AGMR, Kalil RAK, Santos LM, Sposito AC, Rech RL, Sousa ACS, Baldissera F, Nascimento BR, Giraldez RRCV, Cavalcanti AB, Pereira SB, Mattos LA, Armaganijan LV, Guimarães HP, Sousa JEMR, Alexander JH, Granger CB, Lopes RD; SECURE-PCI Investigators. Berwanger O, et al. JAMA. 2018 Apr 3;319(13):1331-1340. doi: 10.1001/jama.2018.2444. JAMA. 2018. PMID: 29525821 Free PMC article. Clinical Trial.

1. Wang CY, Liu PY, Liao JK. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med 2008;14:37-44. 10.1016/j.molmed.2007.11.004 - DOI - PMC - PubMed
1. Hwang DS, Shin ES, Kim SJ, et al. Early differential changes in coronary plaque composition according to plaque stability following statin initiation in acute coronary syndrome: classification and analysis by intravascular ultrasound-virtual histology. Yonsei Med J 2013;54:336-44. 10.3349/ymj.2013.54.2.336 - DOI - PMC - PubMed
1. Taguchi I, Oda K, Yoneda S, et al. Evaluation of serial changes in tissue characteristics during statin-induced plaque regression using virtual histology-intravascular ultrasound studies. Am J Cardiol 2013;111:1246-52. 10.1016/j.amjcard.2013.01.265 - DOI - PubMed
1. Takata K, Imaizumi S, Zhang B, et al. Stabilization of high-risk plaques. Cardiovasc Diagn Ther 2016;6:304-21. 10.21037/cdt.2015.10.03 - DOI - PMC - PubMed
1. Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: a randomized controlled trial. JAMA 2001;285:1711-8. 10.1001/jama.285.13.1711 - DOI - PubMed