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Review
. 2019 Jan;66(1):e27407.
doi: 10.1002/pbc.27407. Epub 2018 Aug 19.

Is the cancer survival improvement in European and American adolescent and young adults still lagging behind that in children?

Annalisa Trama  1 , Alice Bernasconi  1 , Martin G McCabe  2 , Marcela Guevara  3   4 , Gemma Gatta  1 , Laura Botta  1 ; RARECAREnet Working Group  1 ; Lynn Ries  5 , Archie Bleyer  6   7
Affiliations
Review

Is the cancer survival improvement in European and American adolescent and young adults still lagging behind that in children?

Annalisa Trama et al. Pediatr Blood Cancer. 2019 Jan.

Abstract

Improvements during 1978 to 2006 in the 5-year survival rate of adolescents and young adults (AYAs, age 15-39) and children with cancers common to both age groups were evaluated for 1978 to 2006 in Europe and the USA. AYAs had absolute survival increases of 25% and 15% in Europe and the USA, respectively, but in both cases, AYA 5-year survival was, as of 2006, 4% lower than those in children. Acute lymphoblastic leukemia (ALL) explained most of the survival difference between AYAs and children on both the continents. In the USA, 20- to 39-year-olds with ALL have had less survival improvement than those in Europe.

Keywords: acute lymphoblastic leukemia; adolescents and young adults; cancer; children; survival; time trends.

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