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. 2018 Sep;24(9):1768-1770.
doi: 10.3201/eid2409.180625.

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea

Yong Jun Choi, Yae-Jean Kim, Dongeun Yong, Jung-Hyun Byun, Taek Soo Kim, Yun Sil Chang, Min Ji Choi, Seung Ah Byeon, Eun Jeong Won, Soo Hyun Kim, Myung Geun Shin, Jong Hee Shin

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea

Yong Jun Choi et al. Emerg Infect Dis. 2018 Sep.

Abstract

We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite typing.

Keywords: Candida parapsilosis; South Korea; antimicrobial resistance; candidemia; drug resistance; fluconazole; fungi; microsatellite marker.

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