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. 1986 Apr;406(4):430-2.
doi: 10.1007/BF00590949.

Electrical and molecular coupling between sodium and proton fluxes in basolateral membrane vesicles of rat liver

R Fuchs, T Thalhammer, M Peterlik, J Graf

Electrical and molecular coupling between sodium and proton fluxes in basolateral membrane vesicles of rat liver

R Fuchs et al. Pflugers Arch. 1986 Apr.

Abstract

Mechanisms of Na+-H+ exchange in the hepatocyte were studied utilizing isolated basolateral membrane vesicles prepared by two different methods: Evidence was obtained for the existence of molecular coupling of Na+ and H+ fluxes (Na+/H+-antiport) which exhibits saturation kinetics (Km 7 mmol/l Na+) and is inhibited by amiloride (1.0 mmol/l). Although the two membrane preparations showed differences with respect to ionic permeabilities, our data suggest that a relatively high H+ conductance exists in the basolateral plasma membrane. Hence, electrical coupling of conductive H+ and Na+ fluxes in the opposite direction could contribute to net Na+-H+ exchange across the basolateral hepatocyte plasma membrane.

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