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. 2018 Dec 1;103(12):4501-4510.
doi: 10.1210/jc.2018-00448.

Preconception Plasma Phospholipid Fatty Acids and Fecundability

Sunni L Mumford  1 , Richard W Browne  2 , Keewan Kim  1 , Christina Nichols  1 , Brian Wilcox  3 , Robert M Silver  4 , Matthew T Connell  1 , Tiffany L Holland  1 , Daniel L Kuhr  1   5   6 , Ukpebo R Omosigho  1 , Neil J Perkins  1 , Rose Radin  1 , Lindsey A Sjaarda  1 , Enrique F Schisterman  1
Affiliations

Preconception Plasma Phospholipid Fatty Acids and Fecundability

Sunni L Mumford et al. J Clin Endocrinol Metab. .

Abstract

Context: Fatty acids (FAs) are important for reproductive processes, including steroidogenesis, though associations with fecundability, as measured by time to pregnancy (TTP), are unclear.

Objective: To investigate the relationship between preconception plasma phospholipid FA (PPFA) levels and time to human chorionic gonadotropin-pregnancy among women with prior pregnancy loss.

Design, setting, and participants: Prospective cohort of 1228 women attempting pregnancy (aged 18 to 40 years, with one or two prior pregnancy losses) followed for up to six cycles at four US university medical centers during 2006 to 2012. PPFA levels were measured at baseline.

Main outcome measures: Associations with fecundability overall and by body mass index (BMI) group after adjusting for confounders were estimated using fecundability odds ratios (FORs) and 95% CIs. False discovery rate (FDR) was used to account for multiple comparisons.

Results: Monounsaturated fatty acids (MUFAs) were associated with increased fecundability or shorter TTP [FOR, 1.08 (95% CI, 1.01 to 1.16) per unit increase in percentage of total FAs], whereas polyunsaturated fatty acids (PUFAs) were associated with decreased fecundability or longer TTP [FOR, 0.95 (95% CI, 0.91 to 1.00) per 1% change], though associations only remained significant after FDR adjustment among women with BMI <25 kg/m2. Saturated FA and trans FA were not associated with fecundability. Omega-3 FAs and omega-6 linoleic acid were not associated with fecundability.

Conclusion: We observed associations between preconception MUFA and PUFA levels and fecundability among women with normal BMI, highlighting the importance of FA composition among normal-weight women with prior pregnancy loss.

Trial registration: ClinicalTrials.gov NCT00467363.

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Figures

Figure 1.
Figure 1.
Results of sensitivity analysis for unmeasured confounding of the PUFA-TTP associations by fish consumption, EAGeR Trial, 2006–2012. Simulations are data-driven, with the association between the unmeasured dietary factor and TTP set to be β = −0.7 (FOR, 0.5), β = 0 (FOR, 1.0), and β = 0.7 (FOR, 2.0) across a range of correlations between the unmeasured dietary factor and FAs from ρ = 0 to 0.8. Open square, unadjusted model. Solid circle, adjusted model. U, unmeasured confounding factor.
Figure 2.
Figure 2.
Results of sensitivity analysis for unmeasured confounding of the MUFA-TTP associations by fish consumption, EAGeR Trial, 2006–2012. Simulations are data-driven with the association between the unmeasured dietary factor and TTP set to be β = −0.7 (FOR, 0.5), β = 0 (FOR, 0), and β = 0.7 (FOR, 2.0) across a range of correlations between the unmeasured dietary factor and FAs from ρ = 0 to 0.8. Open square, unadjusted model. Solid circle, adjusted model. U, unmeasured confounding factor.
See this image and copyright information in PMC

References

    1. Sturmey RG, Reis A, Leese HJ, McEvoy TG. Role of fatty acids in energy provision during oocyte maturation and early embryo development. Reprod Domest Anim. 2009;44(Suppl 3):50–58. - PubMed
    1. Wathes DC, Abayasekara DR, Aitken RJ. Polyunsaturated fatty acids in male and female reproduction. Biol Reprod. 2007;77(2):190–201. - PubMed
    1. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003;108(2):155–160. - PubMed
    1. Saldeen P, Saldeen T. Women and omega-3 fatty acids. Obstet Gynecol Surv. 2004;59(10):722–730. - PubMed
    1. Missmer SA, Chavarro JE, Malspeis S, Bertone-Johnson ER, Hornstein MD, Spiegelman D, Barbieri RL, Willett WC, Hankinson SE. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod. 2010;25(6):1528–1535. - PMC - PubMed

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