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Review
. 2018 Aug;118(2):356-361.
doi: 10.1002/jso.25154. Epub 2018 Aug 19.

Fluorescence-guided surgery for high-grade gliomas

Nikita Lakomkin  1   2 , Constantinos G Hadjipanayis  1   2
Affiliations
Review

Fluorescence-guided surgery for high-grade gliomas

Nikita Lakomkin et al. J Surg Oncol. 2018 Aug.

Abstract

5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.

Keywords: 5-aminolevulinic acid (5-ALA); glioblastoma multiforme (GBM); photodynamic therapy.

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