Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jun;83(12):4489-93.
doi: 10.1073/pnas.83.12.4489.

High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes

G Angelini, C de Preval, J Gorski, B Mach

High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes

G Angelini et al. Proc Natl Acad Sci U S A. 1986 Jun.

Erratum in

  • Proc Natl Acad Sci U S A 1986 Sep;83(17):6664

Abstract

The human major histocompatibility complex class II antigens of the HLA-D are highly polymorphic, surface proteins essential in the cellular interactions necessary for an immune response. The analysis of this polymorphism is crucial for (i) histocompatibility matching for transplantation and (ii) understanding the association between HLA-D and certain important diseases. The polymorphism of certain HLA-D haplotypes may escape detection by current methodologies. Analysis at the genomic level of the polymorphism of one of the HLA-D subregions HLA-DR, using oligonucleotide probes specific for the polymorphic regions, is capable of distinguishing single nucleotide differences. The DRw6 haplotype was analyzed in view of the lack of DRw6 specific sera. On the basis of nucleotide sequence analysis, the DRw6 haplotype consists of at least two subtypes. When analyzed with oligonucleotide probes, this split identifies new polymorphic groups that differ from the DRw6 serological subgroups.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1984 Jul;81(13):3934-8 - PubMed
    1. Cell. 1984 Jan;36(1):1-13 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(10):3405-9 - PubMed
    1. Hum Immunol. 1985 Jun;13(2):95-103 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5165-9 - PubMed

Publication types

Substances

Associated data