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. 2018 Sep;15(9):693-696.
doi: 10.1038/s41592-018-0103-2. Epub 2018 Aug 20.

Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

Isaac Canals  1   2   3 , Aurélie Ginisty  1   2   3 , Ella Quist  1   2   3 , Raissa Timmerman  1   2   3 , Jonas Fritze  1   2   3 , Giedre Miskinyte  2   3   4 , Emanuela Monni  2   3   4 , Marita G Hansen  3 , Isabel Hidalgo  3   5 , David Bryder  3   5 , Johan Bengzon  3   6 , Henrik Ahlenius  7   8   9
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Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

Isaac Canals et al. Nat Methods. 2018 Sep.

Erratum in

Abstract

The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes and were deemed suitable for disease modeling. Our method provides new possibilities for the study of human astrocytes in health and disease.

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