Squamous cell carcinoma of the spleen: A case report

Abstract

Tumor incidence in the spleen is relatively low compared with that in other organs. The majority of primary splenic tumors are benign, and the majority of malignant tumors are lymphoma or fibrosarcoma. While the occurrence of single squamous cell carcinoma in the spleen is rare, the present study reports a case of single splenic squamous cell carcinoma in which the patient received surgery, chemotherapy and Chinese herbal treatment, and died 14 months after diagnosis. As to the best of our knowledge this case type has not been previously reported; the present study provides insight into the response for standard treatment and the prognosis of the splenic squamous cell carcinoma for a single case.

Keywords: pathological examination immunohistochemistry; primary tumor positron emission tomography-computed tomography; splenic squamous cell carcinoma.

Figure 1.

(A and B) Microscopic images of squamous cell carcinoma of the spleen [hematoxylin and eosin staining; magnification, (A) ×40 and (B) ×100]. Immunohistochemical staining of the tumor cells for (C) creatine kinase, (D) p40, (E) p63 and (F) cluster of differentiation 34, (G) cytokeratin 7, (H) leucocyte common antigen, (I) p53 and (J) thyroid transcription factor-1 (magnification, ×100).

Figure 2.

(A) The left is an anatomical image of the cross section of the spleen, the right is a functional image, the spleen near the tail of the pancreas shows a soft tissue density which is slightly increased in glucose metabolism (23×22 mm, SUVmax 6.4) (B) The left is a fusion image of two images of (A). The right is a whole-body functional image, which demonstrated there is no other abnormal density in glucosemetabolism. PET-CT, positron emission tomography-computed tomography; SUV, standard uptake value.