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. 2018 Sep;29(9):966-970.
doi: 10.1089/hum.2018.066. Epub 2018 Aug 21.

One Group's Historical Reflections on DNA Vaccine Development

Ellen F Fynan  1 , Shan Lu  2 , Harriet L Robinson  3
Affiliations

One Group's Historical Reflections on DNA Vaccine Development

Ellen F Fynan et al. Hum Gene Ther. 2018 Sep.

Abstract

DNA vaccines were pioneered by several groups in the early 1990s. This article presents the reflections of one of these groups on their work with retroviral vectors in chickens that contributed to the discovery and early development of DNA vaccines. Although the findings were initially met with skepticism, the work presented here combined with that of others founded a new method of vaccination: the direct inoculation of purified DNA encoding the target antigen.

Keywords: DNA vaccines; antibody; cytotoxic T cells; heterologous prime-boost.

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Conflict of interest statement

H.L.R. currently works for GeoVax, Inc., which is advancing a DNA prime-MVA boost vaccine. She owns stock in GeoVax as well as being on patents. S.L. is on DNA vaccine-related patents. E.F.F. is on DNA vaccine-related patents.

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