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Review
. 2019 Jan:75-76:1-11.
doi: 10.1016/j.matbio.2018.08.007. Epub 2018 Aug 18.

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Nikos K Karamanos  1 , Achilleas D Theocharis  2 , Thomas Neill  3 , Renato V Iozzo  3
Affiliations
Review

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Nikos K Karamanos et al. Matrix Biol. 2019 Jan.

Abstract

The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.

Keywords: Cancer; Collagens; Proteases; Proteoglycans; Senescence.

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Conflict of interest statement

Conflicts of interest

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic depiction of matrix modeling and remodeling driven by SASP and various proteolytic effectors including MMPs and cathepsins. Please consult the text for additional information.
Fig. 2.
Fig. 2.
Schematic representation of various roles discovered for proteoglycans in regulating development, as biomarkers in adverse cardiac events, and in controlling tumorigenesis and catabolism. Please refer to the text for additional information.
See this image and copyright information in PMC

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