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Comment
. 2018 Sep;28(9):875-876.
doi: 10.1038/s41422-018-0081-z.

m6A reader suppression bolsters HSC expansion

Xinxin Huang  1 , Hal E Broxmeyer  2
Affiliations
Comment

m6A reader suppression bolsters HSC expansion

Xinxin Huang et al. Cell Res. 2018 Sep.
No abstract available

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Figures

Fig. 1
Fig. 1
In wild-type cells, m6A reader Ythdf2 recognizes m6A-modified RNAs and thus targets these RNAs for degradation (left). In the present study, Li et al. demonstrate that Ythdf2 deficiency results in increased stability of m6A-modified RNAs, leading to elevated expression of HSC self-renewal factors and increased HSC numbers (right)
See this image and copyright information in PMC

Comment on

  • Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.
    Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Li Z, et al. Cell Res. 2018 Sep;28(9):904-917. doi: 10.1038/s41422-018-0072-0. Epub 2018 Jul 31. Cell Res. 2018. PMID: 30065315 Free PMC article.

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