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Editorial
. 2018 Jul 27;9(58):31169-31170.
doi: 10.18632/oncotarget.25798.

Redaporfin induces immunogenic cell death by selective destruction of the endoplasmic reticulum and the Golgi apparatus

Lígia Catarina Gomes-da-Silva  1   2 , Liwei Zhao  1   2 , Luis G Arnaut  1   2 , Guido Kroemer  1   2 , Oliver Kepp  1   2
Affiliations
Editorial

Redaporfin induces immunogenic cell death by selective destruction of the endoplasmic reticulum and the Golgi apparatus

Lígia Catarina Gomes-da-Silva et al. Oncotarget. .
No abstract available

Keywords: ER stress; Golgi damage; immunogenic cell death; photodynamic therapy; redaporfin.

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Figures

Figure 1
Figure 1. Redaporfin-induced cellular stress and compartmental alteration
(A) Redaporfin accumulates in the endoplasmic reticulum (ER) and Golgi apparatus (GA). Photoactivation of redaporfin triggers the generation of reactive oxygen species (ROS), which in turn leads to local damage, dysfunction of the ER/GA network and impairment of global protein secretion. In addition, redaporfin-induced ER/GA damage operates upstream of mitochondria to induce apoptosis. In vivo the photodynamic therapy with redaporfin triggers cell death of the primary tumor and elicits antitumor immunity that is able to control distant leasions.
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