Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jun;53(6):793-7.
doi: 10.1038/bjc.1986.134.

The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts

S Sparrow, M Jones, S Billington, B Stace
Free PMC article

The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts

S Sparrow et al. Br J Cancer. 1986 Jun.
Free PMC article

Abstract

During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumours over successive transplant generations. These sarcomas had growth rates, tumour karyotypes and isoenzyme patterns which clearly distinguished them from the original human xenografts.

PubMed Disclaimer

References

    1. Acta Pathol Microbiol Scand. 1969;77(4):758-60 - PubMed
    1. Nat New Biol. 1972 Sep 20;239(90):83-4 - PubMed
    1. J Natl Cancer Inst. 1973 Aug;51(2):707-11 - PubMed
    1. J Exp Med. 1976 Jan 1;143(1):225-31 - PubMed
    1. Br J Cancer. 1978 Feb;37(2):199-212 - PubMed