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. 2019 Jan;56(1):e13277.
doi: 10.1111/psyp.13277. Epub 2018 Aug 22.

Increased stressor-evoked cardiovascular reactivity is associated with reduced amygdala and hippocampus volume

Gavin P Trotman  1 , Peter J Gianaros  2 , Jet J C S Veldhuijzen van Zanten  1 , Sarah E Williams  1 , Annie T Ginty  3
Affiliations

Increased stressor-evoked cardiovascular reactivity is associated with reduced amygdala and hippocampus volume

Gavin P Trotman et al. Psychophysiology. 2019 Jan.

Abstract

Exaggerated cardiovascular reactivity to acute psychological stress is associated with an increased risk of developing cardiovascular disease. The amygdala and hippocampus have been implicated in centrally mediating stressor-evoked cardiovascular reactivity. However, little is known about the associations of amygdala and hippocampus morphology with stressor-evoked cardiovascular reactivity. Forty (Mage = 19.05, SD = 0.22 years) healthy young women completed two separate testing sessions. Session 1 assessed multiple parameters of cardiovascular physiology at rest and during a validated psychological stress task (Paced Auditory Serial Addition Test), using electrocardiography, Doppler echocardiography, and blood pressure monitoring. In Session 2, 1 year later, structural MRI was conducted. Brain structural volumes were computed using automated segmentation methods. Regression analyses, following Benjamini-Hochberg correction, showed that greater heart rate and cardiac output reactivity were associated with reduced amygdala and hippocampus gray matter volume. Systolic blood pressure reactivity was associated with reduced hippocampus volume. In contrast, no associations between diastolic blood pressure, mean arterial blood pressure, stroke volume, or total peripheral resistance reactivity with amygdala or hippocampus volumes were apparent. Comparison analyses examining insula volume found no significant associations. Some indicators of greater stressor-evoked cardiovascular reactivity associate with reduced amygdala and hippocampus gray matter volume, but the mechanisms of this association warrant further study.

Keywords: amygdala; brain morphology; hippocampus; individual differences; magnetic resonance imaging; psychological stress; stressor-evoked cardiovascular reactivity.

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Figures

Figure 1
Figure 1
Scatterplots showing unadjusted amygdala volume plotted against (a) heart rate reactivity (b) systolic blood pressure reactivity (c) diastolic blood pressure reactivity (d) mean arterial pressure reactivity (e) stroke volume reactivity (f) cardiac output reactivity (g) total peripheral resistance reactivity. *p < 0.05, **p < 0.01
Figure 2
Figure 2
Scatterplots showing unadjusted hippocampus volume plotted against (a) heart rate reactivity (b) systolic blood pressure reactivity (c) diastolic blood pressure reactivity (d) mean arterial pressure reactivity (e) stroke volume reactivity (f) cardiac output reactivity (g) total peripheral resistance reactivity. *p < 0.05
Figure 3
Figure 3
Scatterplots showing unadjusted insula volume plotted against (a) heart rate reactivity (b) systolic blood pressure reactivity (c) diastolic blood pressure reactivity (d) mean arterial pressure reactivity (e) stroke volume reactivity (f) cardiac output reactivity (g) total peripheral resistance reactivity
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