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Editorial
. 2018 Sep;48(6):682-683.
doi: 10.1111/apt.14864.

Editorial: control of acid secretion

G Sachs  1 , E A Marcus  1 , Y Wen  1 , K Munson  1
Affiliations
Editorial

Editorial: control of acid secretion

G Sachs et al. Aliment Pharmacol Ther. 2018 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Structures of vonoprazan fumarate and DWP14012 hydrochloride. The benefits of these two P-CABs are predicted to be: (1) Elevation of pH to >5.0, 24 hours from a single dose; (2) Improved treatment of acid-related diseases; (3) Eradication of H. pylori in combination with amoxicillin only; (4) Immediate onset of action; (5) No requirement for enteric coating; (6) Meal independence; (7) Easy solution formulation. A dose of 40 mg once a day would maintain a pH >5.0 for 24 hours per day.
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References

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