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Comment
. 2018 Aug 21;49(2):206-208.
doi: 10.1016/j.immuni.2018.08.005.

Human cGAS Has a Slightly Different Taste for dsDNA

Alexiane Decout  1 , Andrea Ablasser  2
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Human cGAS Has a Slightly Different Taste for dsDNA

Alexiane Decout et al. Immunity. .
Free article

Abstract

The nucleotidyltransferase cGAS performs a crucial role in innate immunity by binding double-stranded DNA and catalyzing the production of cGAMP. A structure of the human cGAS-DNA complex reported in Cell provides a fresh perspective on its mechanism of activation.

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