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. 2019 Jun;32(11):1915-1923.
doi: 10.1080/14767058.2017.1419177. Epub 2018 Aug 23.

Criteria for assigning cause of death for stillbirths and neonatal deaths in research studies in low-middle income countries

Robert L Goldenberg  1 , Lulu Muhe  2 , Sarah Saleem  3 , Sangappa Dhaded  4 , Shivaprasad S Goudar  4 , Janna Patterson  5 , Assaye Nigussie  5 , Elizabeth M McClure  6
Affiliations

Criteria for assigning cause of death for stillbirths and neonatal deaths in research studies in low-middle income countries

Robert L Goldenberg et al. J Matern Fetal Neonatal Med. 2019 Jun.

Abstract

Accurate knowledge regarding cause of death (COD) for stillbirths and neonatal deaths is crucial, especially in low-income countries, in order for public health and medical officials to choose appropriate interventions likely to reduce these deaths. To date, many of the COD studies in these areas have relied only on obstetric or neonatal clinical information and the determination of COD is likely to be inaccurate. Information related to infectious COD is especially lacking. Thus, without more sophisticated testing, data as currently collected only provide a very weak approximation of the COD and may well lead to adoption of interventions of limited usefulness. In this commentary, we propose recommendations regarding the type of data needed to determine with reasonable accuracy the COD for stillbirths and neonatal deaths in low-resource settings. Using these data, and a method to determine the degree of certainty, we then propose definitions for the most common COD. Our goal is to reduce subjectivity and provide more specificity for the tests used in existing classification systems so that the methodology of COD determination is transparent and able to be replicated over time and from location to location.

Keywords: Neonatal mortality; autopsy; cause of death; low/middle-income countries; minimum invasive tissue sampling; stillbirth.

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Conflict of interest statement

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

References

    1. Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015;385(9966):430–440. - PubMed
    1. Blencowe H, Cousens S, Jassir FB, et al. National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health 2016;4(2):e98–e108. - PubMed
    1. Lawn JE, Blencowe H, Waiswa P, et al. Stillbirths: rates, risk factors, and acceleration towards 2030. Lancet 2016;387(10018):587–603. - PubMed
    1. GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388(10053):1725–1774. - PMC - PubMed
    1. Blencowe H, Cousens S, Chou D, et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health 2013;10(Suppl1):S2. - PMC - PubMed

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