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Review
. 2018 Aug 14:7:F1000 Faculty Rev-1283.
doi: 10.12688/f1000research.13898.1. eCollection 2018.

Understanding depression in type 2 diabetes: a biological approach in observational studies

Thomas van Sloten  1   2   3 , Miranda Schram  1   2   4
Affiliations
Review

Understanding depression in type 2 diabetes: a biological approach in observational studies

Thomas van Sloten et al. F1000Res. .

Abstract

Depression is twice as common in type 2 diabetes as in the general population and is associated with adverse health outcomes. Growing evidence suggest that type 2 diabetes and depression share biological mechanisms. This brief commentary discusses current understanding of shared biological pathways, focussing on hyperglycaemia, (micro)vascular dysfunction, and low-grade inflammation. Although there is accumulating evidence that these pathways are involved in the link between type 2 diabetes and depression, direct evidence of their temporal associations is lacking because of a paucity of longitudinal studies that focus on the pathobiology of both type 2 diabetes and depression.

Keywords: (micro-)vascular dysfunction; depression; hyperglycaemia; low-grade inflammation; type 2 diabetes.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

References

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