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Book

Sarcoma

John R. Popovich, Sarang Kashyap  1 , David P. Gasalberti  2 , Sebastiano Cassaro  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Sarcoma

John R. Popovich et al.
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Excerpt

Soft tissue sarcomas (STS) are a group of more than 60 different neoplasms that can originate from any location throughout the human body and affect individuals at the extremes of age. From skeletal muscle, adipose tissue, blood, and lymphatics to connective tissue and peripheral nerves, these neoplasms can span a range of clinical presentations from benign lipomas to aggressive metastatic angiosarcomas. The real challenge in diagnosing these conditions is that several non-neoplastic conditions mimic STS. Soft tissue sarcomas are separated categorically as trunk and extremity from retroperitoneum. The majority of STS occurs spontaneously. However, germline mutations, radiation, and environmental exposure(s) have been causative.

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Conflict of interest statement

Disclosure: John Popovich declares no relevant financial relationships with ineligible companies.

Disclosure: Sarang Kashyap declares no relevant financial relationships with ineligible companies.

Disclosure: David Gasalberti declares no relevant financial relationships with ineligible companies.

Disclosure: Sebastiano Cassaro declares no relevant financial relationships with ineligible companies.

References

    1. Singhi EK, Moore DC, Muslimani A. Metastatic Soft Tissue Sarcomas: A Review Of Treatment and New Pharmacotherapies. P T. 2018 Jul;43(7):410-429. - PMC - PubMed
    1. Duncan MA, Lautner MA. Sarcomas of the Breast. Surg Clin North Am. 2018 Aug;98(4):869-876. - PubMed
    1. Skoda J, Veselska R. Cancer stem cells in sarcomas: Getting to the stemness core. Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2134-2139. - PubMed
    1. Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. Nat Rev Dis Primers. 2018 Jul 05;4(1):5. - PubMed
    1. Kondo T. Current Status of Proteomics in Ewing's Sarcoma. Proteomics Clin Appl. 2019 May;13(3):e1700130. - PubMed

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