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. 2019 Jan 28;400(2):237-246.
doi: 10.1515/hsz-2018-0265.

MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B

Peng Sun  1 , Dan Zhang  1 , Haiping Huang  1 , Yafeng Yu  1 , Zhendong Yang  1 , Yuyu Niu  1 , Jisheng Liu  1
Affiliations

MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B

Peng Sun et al. Biol Chem. .

Abstract

This study aimed to investigate the role of miRNA-1225-5p (miR-1225) in laryngeal carcinoma (LC). We found that the expression of miR-1225 was suppressed in human LC samples, while CDC14B (cell division cycle 14B) expression was reinforced in comparison with surrounding normal tissues. We also demonstrated that enhanced expression of miR-1225 impaired the proliferation and survival of LC cells, and resulted in G1/S cell cycle arrest. In contrast, reduced expression of miR-1225 promoted cell survival. Moreover, miR-1225 resulted in G1/S cell cycle arrest and enhanced cell death. Further, miR-1225 targets CDC14B 3'-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on LC cells. Thus, these findings offer insight into the biological and molecular mechanisms behind the development of LC.

Keywords: CDC14B; cell cycle; cell death; laryngeal cancer; miR-1225-5p.

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