Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Aug 23;14(8):e1007534.
doi: 10.1371/journal.pgen.1007534. eCollection 2018 Aug.

C. elegans RAB-35: Dual roles in apoptotic cell clearance

Christian E Rocheleau  1   2   3
Affiliations
Comment

C. elegans RAB-35: Dual roles in apoptotic cell clearance

Christian E Rocheleau. PLoS Genet. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Model of RAB-35 regulation and function during early phagosome maturation.
FLCN-1 activates RAB-35 downstream of an unknown signal, possibly integrin, promoting phagosome localization. RAB-35 functions parallel to CED-1 to promote the removal of PI(4,5)P and MTM-1, thus permitting the accumulation of PI(3)P. RAB-35, CED-1, and PI(3)P may promote RAB-5 recruitment and activation on maturing phagosomes. The RAB-35 effector(s) that mediate these events are not yet known and are thus depicted by dashed lines. RAB-35 would then be inactivated by TBC-10, which theoretically could be recruited by RAB-5 or other factors on the maturing phagosome.
See this image and copyright information in PMC

Comment on

References

    1. Poon IK, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 2014;14(3):166–80. Epub 2014/02/01. 10.1038/nri3607 ; PubMed Central PMCID: PMCPMC4040260. - DOI - PMC - PubMed
    1. Haley RC, Wang Y, Zhou Z. The small GTPase RAB-35 leads a third pathway to aid the recognition and 3 degradation of apoptotic cells. PLoS Genet. 2018. - PMC - PubMed
    1. Wang X, Yang C. Programmed cell death and clearance of cell corpses in Caenorhabditis elegans. Cell Mol Life Sci. 2016;73(11–12):2221–36. Epub 2016/04/07. 10.1007/s00018-016-2196-z . - DOI - PMC - PubMed
    1. Malin JZ, Shaham S. Cell Death in C. elegans Development. Curr Top Dev Biol. 2015;114:1–42. Epub 2015/10/04. 10.1016/bs.ctdb.2015.07.018 ; PubMed Central PMCID: PMCPMC5206663. - DOI - PMC - PubMed
    1. Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics. 1991;129(1):79–94. Epub 1991/09/01. ; PubMed Central PMCID: PMCPMC1204584. - PMC - PubMed

Substances

LinkOut - more resources