. 2018 Aug 23;8(8):e021643.

doi: 10.1136/bmjopen-2018-021643.

International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan

Veronica Neves Fialho Queiroz¹, Luiz Guilherme Villares da Costa¹, Rogerio Póvoa Barbosa¹, Flávio Takaoka¹, Luc De Baerdemaeker², Daniel Souza Cesar¹, Ulisses Cardoso D'Orto¹, José Roberto Galdi¹, Vijaya Gottumukkala³, Juan P Cata³, Sabrine N T Hemmes^{4

5}, Markus W Hollman⁵, Alain Kalmar^{6

7}, Lucas A B de Moura¹, Renato M Mariano¹, Idit Matot⁸, Guido Mazzinari⁹, Gary H Mills¹⁰, Irimar de Paula Posso¹, Alexandre Teruya^{1

11}, Marcos Francisco Vidal Melo¹², Juraj Sprung¹³, Toby N Weingarten¹³, Tanja A Treschan¹⁴, Seppe Koopman¹⁵, Leonid Eidelman¹⁶, Lee-Lynn Chen¹⁷, Jae-Woo Lee¹⁷, Jose J Ariño Irujo¹⁸, Beatriz Tena¹⁹, Harald Groeben²⁰, Paolo Pelosi²¹, Marcelo Gama de Abreu²², Marcus J Schultz^{4

23}, Ary Serpa Neto^{4

24}; AVATaR and PROVE Network investigators

Affiliations

¹ Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
² Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.
³ Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.
⁵ Department of Anaesthesiology, Academic Medical Center, Amsterdam, The Netherlands.
⁶ Department of Anesthesia and Intensive Care Medicine, Maria Middelares Hospital, Ghent, Belgium.
⁷ Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁸ Division of Anesthesiology, Intensive Care and Pain, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
⁹ Department of Anaesthesiology, Manises Hospital, Valencia, Spain.
¹⁰ Department of Anaesthesia and Critical Care Medicine, Sheffield Teaching Hospital, Sheffield, UK.
¹¹ Department of Anesthesiology, Hospital Moriah, São Paulo, Brazil.
¹² Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹³ Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Anesthesiology, Düsseldorf University Hospital, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany.
¹⁵ Department of Anaesthesiology, Maasstad Ziekenhuis, Rotterdam, The Netherlands.
¹⁶ Department of Anesthesia, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
¹⁷ Department of Anesthesia and Perioperative Care, University of California-San Francisco, San Francisco, California, USA.
¹⁸ Department of Anesthesia, Hospital Clínico San Carlos, Madrid, Spain.
¹⁹ Department of Anesthesiology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
²⁰ Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Kliniken Essen-Mitte, Essen, Germany.
²¹ Department of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology, University of Genoa, Genoa, Italy.
²² Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
²³ Mahidol Oxford Research Unit (MORU), Mahidol University, Bangkok, Thailand.
²⁴ Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.

PMID: 30139899
PMCID: PMC6112402
DOI: 10.1136/bmjopen-2018-021643

International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan

Veronica Neves Fialho Queiroz et al. BMJ Open. 2018.

. 2018 Aug 23;8(8):e021643.

doi: 10.1136/bmjopen-2018-021643.

Authors

Affiliations

¹ Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
² Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.
³ Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.
⁵ Department of Anaesthesiology, Academic Medical Center, Amsterdam, The Netherlands.
⁶ Department of Anesthesia and Intensive Care Medicine, Maria Middelares Hospital, Ghent, Belgium.
⁷ Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁸ Division of Anesthesiology, Intensive Care and Pain, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
⁹ Department of Anaesthesiology, Manises Hospital, Valencia, Spain.
¹⁰ Department of Anaesthesia and Critical Care Medicine, Sheffield Teaching Hospital, Sheffield, UK.
¹¹ Department of Anesthesiology, Hospital Moriah, São Paulo, Brazil.
¹² Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
¹³ Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
¹⁴ Department of Anesthesiology, Düsseldorf University Hospital, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany.
¹⁵ Department of Anaesthesiology, Maasstad Ziekenhuis, Rotterdam, The Netherlands.
¹⁶ Department of Anesthesia, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
¹⁷ Department of Anesthesia and Perioperative Care, University of California-San Francisco, San Francisco, California, USA.
¹⁸ Department of Anesthesia, Hospital Clínico San Carlos, Madrid, Spain.
¹⁹ Department of Anesthesiology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
²⁰ Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Kliniken Essen-Mitte, Essen, Germany.
²¹ Department of Surgical Sciences and Integrated Diagnostics, San Martino Policlinico Hospital, IRCCS for Oncology, University of Genoa, Genoa, Italy.
²² Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
²³ Mahidol Oxford Research Unit (MORU), Mahidol University, Bangkok, Thailand.
²⁴ Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.

PMID: 30139899
PMCID: PMC6112402
DOI: 10.1136/bmjopen-2018-021643

Abstract

Introduction: Robotic-assisted surgery (RAS) has emerged as an alternative minimally invasive surgical option. Despite its growing applicability, the frequent need for pneumoperitoneum and Trendelenburg position could significantly affect respiratory mechanics during RAS. AVATaR is an international multicenter observational study aiming to assess the incidence of postoperative pulmonary complications (PPC), to characterise current practices of mechanical ventilation (MV) and to evaluate a possible association between ventilatory parameters and PPC in patients undergoing RAS.

Methods and analysis: AVATaR is an observational study of surgical patients undergoing MV for general anaesthesia for RAS. The primary outcome is the incidence of PPC during the first five postoperative days. Secondary outcomes include practice of MV, effect of surgical positioning on MV, effect of MV on clinical outcome and intraoperative complications.

Ethics and dissemination: This study was approved by the Institutional Review Board of the Hospital Israelita Albert Einstein. The study results will be published in peer-reviewed journals and disseminated at international conferences.

Trial registration number: NCT02989415; Pre-results.

Keywords: general anesthesia; mechanical ventilation; postoperative pulmonary complications; robotic surgery.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

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References

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International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan

Affiliations

International multicenter observational study on assessment of ventilatory management during general anaesthesia for robotic surgery and its effects on postoperative pulmonary complication (AVATaR): study protocol and statistical analysis plan

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Associated data

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical