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Comment
. 2018 Sep 4;115(36):8852-8854.
doi: 10.1073/pnas.1812779115. Epub 2018 Aug 23.

The bacterial outer membrane is an evolving antibiotic barrier

Kerrie L May  1   2   3 , Marcin Grabowicz  4   2   3
Affiliations
Comment

The bacterial outer membrane is an evolving antibiotic barrier

Kerrie L May et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Architecture of the gram-negative envelope. The OM and IM are separated by an aqueous periplasm. OM lipids are symmetrically distributed, with the surface glycolipids (LPS/LOS) being held together via divalent cation bridging. PLs are in the inner leaflet but can mislocalize when the OM is damaged. The PldA and Mla pathways work together to remove mislocalized PLs and restore asymmetry. In LOS-deficient cells, constitutive activity of PldA and Mla is deleterious as the cell attempts to maintain an OM lipid bilayer.
See this image and copyright information in PMC

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