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. 2018 Sep 11;54(73):10316-10319.
doi: 10.1039/c8cc06185h.

Asymmetric total synthesis of pleurospiroketals A and B

Toyoharu Kobayashi  1 , Konomi Tanaka, Masako Ishida, Natsumi Yamakita, Hideki Abe, Hisanaka Ito
Affiliations

Asymmetric total synthesis of pleurospiroketals A and B

Toyoharu Kobayashi et al. Chem Commun (Camb). .

Abstract

The first asymmetric total synthesis of pleurospiroketals A and B has been accomplished in 16 steps from 5-methyl-5-hexenoic acid. Key features of the synthesis are the highly syn-selective Evans aldol reaction, ring-closing metathesis, highly diastereoselective dihydroxylation and acid-mediated spiroketalization.

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