Clinical diagnosis for dusk phenomenon of diabetes

Abstract

The diabetes dusk phenomenon (spontaneous and transient pre-dinner hyperglycemia) anecdotally exists but has not been investigated.A total of 80 diabetic patients that received continuous subcutaneous insulin infusions were retrospectively studied. They were grouped into a routine group (R) (consecutive δDG [dusk blood glucose difference] <0 mmol/L) and a classic dusk phenomenon group (CDP, consecutive δDG≥0 mmol/L). δDG represents differences in blood glucose measurements between pre-dinner and post-lunch (δDG: dusk blood glucose difference). Other patients were placed in a suspicious group (S). The suspicious group was further divided into 3 groups based on the frequency at which the δDG occurred: suspicious 1 group (S1), δDG≥0 mmol/L occurred once only; suspicious 3 group (S3), δDG < 0 mmol/L occurred once only, and the remaining patients were grouped in the suspicious 2 group (S2).We identified the CDP and S3 groups as the "clinical dusk phenomenon" group (CLDP). We confirmed that the S1 and R groups to be in the "clinical routine" group. The S2 group was significantly different from the CDP group. In addition, the S2 group had significant differences in δDG measurements and post-lunch blood glucose values compared with the R group, but no differences in other parameters were seen. Multiple comparisons with the other suspicious groups also showed no statistical difference in many parameters. Thus, we placed these patients into the "suspicious clinical dusk phenomenon" group (SDP). The δDG cut-off for the CLDP group was 1.0167 mmol/L. The pre-dinner-pre-lunch blood glucose cut-off for this group was 2.72 mmol/L. The δDG cut-off for the SDP group was -0.95 mmol/L. The pre-dinner-pre-lunch blood glucose cut-off for this group was 0.87 mmol/L. The cut-off points for the post-dinner-post-lunch blood glucose measurements in the CLDP and SDP groups were both 1.2667 mmol/L.A consecutive δDG≥0 or a once only δDG < 0 could be diagnosed as falling into the CLDP group. The CLDP could be excluded when a consecutive δDG < 0 or a once only δDG≥0 was found. Patients falling into other categories were placed into the SDP group.

Figure 1

Line chart showing the average blood glucose value in each group.

Figure 2

Bar chart showing the average blood glucose difference (bar Chart of the δDG ratios) δDG (pre-dinner-post-lunch blood glucose). δDG = (dusk blood glucose difference).

Figure 3

Bar chart showing the average blood glucose difference (bar chart of the pre-dinner-pre-lunch blood glucose).

Figure 4

Bar chart showing the average blood glucose difference (bar chart of the post-dinner-post-lunch blood glucose).

Figure 5

Best cut-off value of dusk phenomenon. The ROC curve of the diabetic clinical dusk phenomenon (CLDP). CLDP = clinical dusk phenomenon, ROC = receiver operating characteristic.

Figure 6

ROC curves of the diabetic suspicious clinical dusk phenomenon (SDP). ROC = receiver operating characteristic, SDP = suspicious clinical dusk phenomenon.