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Comment
. 2018 Oct;8(10):1202-1203.
doi: 10.1158/2159-8290.CD-NB2018-115. Epub 2018 Aug 24.

T-Cell Mutation Leads to GI Polyps

No authors listed
Comment

T-Cell Mutation Leads to GI Polyps

No authors listed. Cancer Discov. 2018 Oct.

Abstract

Peutz-Jeghers syndrome, a cancer predisposition syndrome that causes benign gastrointestinal polyps, results from a germline mutation in a single allele of STK11, the gene that encodes for LKB1. Researchers established a possible mechanism for how a STK11 mutation in T cells could lead to polyps associated with the syndrome.

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  • LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.
    Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. Poffenberger MC, et al. Science. 2018 Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975. Science. 2018. PMID: 30049881

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