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Comment
. 2018 Oct 1;150(10):1356-1359.
doi: 10.1085/jgp.201812161. Epub 2018 Aug 24.

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA

Lucie Delemotte  1
Affiliations
Comment

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA

Lucie Delemotte. J Gen Physiol. .

Abstract

Delemotte appraises new computational work revealing that the intracellular activation gate must open for C-type inactivation to occur in K+ channels.

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Figures

Figure 1.
Figure 1.
Representative configurations and key molecular determinants of the closed/conductive, partially open/conductive, and fully open/conductive states of KcsA. Three of four subunits of the channel are displayed as gray ribbons, SF-bound K+ ions are yellow spheres, and inactivating water molecules in one of the subunits are red and white spheres. Key residues are shown as sticks: T74, green; G77, orange; I100, cyan; F103, blue; T112, purple. Opening of the activation gate is shown to be slow while inactivation of the SF is fast.
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References

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