Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan;10(1):29-31.
doi: 10.1111/jdi.12918. Epub 2018 Sep 24.

Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

Chi Ho Lee  1   2 , Karen Sl Lam  1   2   3
Affiliations

Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle

Chi Ho Lee et al. J Diabetes Investig. 2019 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The relationship between adipose tissue insulin resistance and inflammation in diet‐induced obesity. ER, endoplasmic reticulum; JNK, c‐Jun NH2‐terminal kinase; NFκB, nuclear factor kappa B.
See this image and copyright information in PMC

References

    1. Weisberg SP, McCann D, Desai M, et al Obesity is associated with macrophage accumulation in adipose tissue. J Clin Investig 2003; 112: 1796–1808. - PMC - PubMed
    1. Shimobayashi M, Albert V, Woelnerhanssen B, et al Insulin resistance causes inflammation in adipose tissue. J Clin Investig 2018; 128: 1538–1550. - PMC - PubMed
    1. Morley TS, Xia JY, Scherer PE. Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements. Nat Commun 2015; 6: 7906. - PMC - PubMed
    1. McCurdy CE, Schenk S, Holliday MJ, et al Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet‐induced obese mice. Diabetes 2012; 61: 2495–2505. - PMC - PubMed
    1. Turner N, Kowalski GM, Leslie SJ, et al Distinct patterns of tissue‐specific lipid accumulation during the induction of insulin resistance in mice by high‐fat feeding. Diabetologia 2013; 56: 1638–1648. - PubMed