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Review
. 2019 Jan;17(2):290-295.
doi: 10.1016/j.cgh.2018.08.045. Epub 2018 Aug 23.

The Gut Microbiome in Pancreatic Disease

Venkata S Akshintala  1 , Rupjyoti Talukdar  2 , Vikesh K Singh  1 , Michael Goggins  3
Affiliations
Review

The Gut Microbiome in Pancreatic Disease

Venkata S Akshintala et al. Clin Gastroenterol Hepatol. 2019 Jan.

Abstract

The gut microbiome increasingly is recognized for its role in human health and disease. Initial evidence has indicated that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate chronic proinflammatory changes in the pancreas. Further mechanistic and epidemiologic studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value.

Keywords: Dysbiosis; Intratumoral Bacteria; Microbiome; Pancreatic Cancer; Pancreatitis; Probiotics.

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Conflict of interest statement

Conflicts statement

Vikesh Singh: Consultant for Abbvie, Ariel Precision Medicine, and Akcea Therapeutics

Rupjyoti Talukdar: Advisory Board member for Abbott India and Dr. Reddy’s Laboratories.

None of the other authors have disclosures

Figures

Figure 1:
Figure 1:
Overview of interactions between gut microbiota and pancreatic disease
See this image and copyright information in PMC

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